62 Fun Facts About LSD

Unlike other classic psychedelics, the origins of LSD don’t trace back to Indigenous cultures. However, it is a fascinating substance that has the potential to improve our lives, treat mental health conditions, and change the way we perceive ourselves. 

We created this list of fun facts about LSD. Remember to bookmark this page when you need a conversation starter at your next dinner party. 

Scientific Facts About LSD

“LSD is considered non-toxic at typical doses, and there is no record of anyone dying from LSD. However, its effects can lead to risky behaviors in unsafe environments.”

— Katharine Chan, MSc, BSc, PMP

Here are 16 facts about the basics, effects, and experiences of LSD:

Basics of LSD

1. Lysergic acid diethylamide (LSD) is a synthetic compound derived from ergot, a fungus that grows on rye and other grains.
2. There are currently no brand names for LSD because it is illegal to sell it.
3. Regulatory authorities classify LSD as a classic psychedelic.
4. Regulatory authorities classify LSD as a Schedule I substance in the United States; however, if the FDA approves it for therapeutic purposes, the legal status of LSD as a medication will change.
5. People often refer to LSD as “acid” or “L”.
6. LSD primarily acts on serotonin receptors (especially the 5-HT2A receptor) in the brain, altering perception, mood, and cognition.
7. LSD is one of the most potent psychoactive substances known, with effective doses measured in micrograms (µg). A typical dose ranges from 75 to 150 µg. Most people can detect LSD’s effects at 25 μg.
8. LSD is considered non-toxic at typical doses, and there is no record of anyone dying from LSD. However, its effects can lead to risky behaviors in unsafe environments.
9. People can take LSD in different forms, such as liquid drops, tablets, or blotting papers.

Effects and Experiences of LSD

10. LSD induces altered states of consciousness, including visual and auditory hallucinations, intensified emotions, changes in time perception, and a sense of interconnectedness.
11. LSD often produces vivid imagery, captivating sensory experiences, and feelings of euphoria, leading to a heightened appreciation of the present moment.
12. LSD can increase creativity, imaginative thinking, and profound insights, often resulting in transformative personal revelations.
13. LSD can contribute to a sense of unity and connectedness with others, nature, and the universe. Along with experiences of ego dissolution, it can also be deeply spiritual or mystical.
14. LSD can cause challenging experiences, such as anxiety, paranoia, and “bad trips,” which may provoke confusion, fear, and significant psychological distress, sometimes with lasting adverse effects on mental well-being.
15. In vulnerable individuals, LSD can worsen or trigger psychological conditions, leading to symptoms like paranoia, delusions, mania, or depression, particularly in those predisposed to disorders like schizophrenia.
16. Adverse physiological effects of LSD include dilated pupils, fluctuations in blood pressure and body temperature, nausea, dizziness, and impaired coordination. It may also disrupt attention, concentration, and physical reaction times.

The Truth About LSD and Drug-Induced Psychosis

Culturally, we’ve associated LSD with “bad trips,” but does this psychedelic indeed cause psychosis? Here are five facts to explain this perception.

1. LSD can occasionally trigger challenging symptoms, such as loss of insight or ego death, which may frighten users, especially those experiencing these states for the first time. However, when integrated properly through psychedelic therapy, therapists can help users explore even fearful episodes safely.
2. The risk of LSD-induced psychosis is higher in individuals with a history of mental health issues like schizophrenia or substance abuse. 
3. LSD may exacerbate underlying conditions, particularly in those predisposed to psychotic disorders, potentially worsening hallucinations or delusions.
4. Though current research excludes people with psychotic disorders, making definitive conclusions challenging, it’s essential that patients consider these risks before pursuing psychedelic therapy.
5. Psychosis is not unique to LSD — other common substances can also induce similar symptoms, such as cannabis, alcohol, and stimulants such as amphetamines, ADHD medications, and caffeine.

Therapeutic Facts About LSD

“Clinical studies show that LSD-assisted therapy can lead to lasting improvements in mental health, even after a single session.”

— Katharine Chan, MSc, BSc, PMP

Here are 14 facts about the therapeutic potential of LSD:

1. LSD-assisted psychotherapy began in 1955, with early studies in the 1950s and 1960s focusing on its pharmacology, cognitive effects, and therapeutic applications in psychedelic and psycholytic therapy.
2. After a decades-long research hiatus following LSD’s prohibition in 1968, interest revived in the 1990s and 2000s, leading to modern studies supported by organizations like the Beckley Foundation and groundbreaking research on LSD’s effects on anxiety and brain function.
3. In 2023, MindMed completed two Phase 2 trials investigating LSD-assisted therapy for anxiety disorders. The FDA granted a breakthrough therapy designation in 2024 for MindMed’s LSD formulation to treat generalized anxiety disorder, signaling promising therapeutic potential.
4. Researchers use LSD to explore its potential in treating depression by promoting emotional processing and self-reflection.
5. Studies demonstrate that LSD can reduce anxiety, particularly in individuals facing existential distress or end-of-life concerns.
6. Therapists utilize LSD to help patients with PTSD access and process traumatic memories in a controlled and supportive setting.
7. Clinical trials show that LSD can assist individuals in overcoming addiction by fostering profound insights and enhancing motivation for change.
8. Therapists report success using LSD to treat alcoholism by encouraging self-awareness and addressing underlying emotional issues.
9. LSD helps patients confront anxiety associated with life-threatening diseases by facilitating acceptance and emotional release.
10. LSD’s ability to enhance sensory perception helps patients reconnect with positive emotions and experiences.
11. Research indicates that LSD-assisted therapy can improve self-esteem and foster a greater sense of purpose in life.
12. LSD encourages introspection and self-awareness, which are critical for addressing unresolved psychological issues.
13. Clinical studies show that LSD-assisted therapy can lead to lasting improvements in mental health, even after a single session.
14. Researchers suggest that LSD may play a role in treating dementia and early Alzheimer’s disease, specifically micro-dosing LSD.

Microdosing LSD Facts

Here are five quick facts about what microdosing LSD involves:

1. LSD microdosing involves taking sub-perceptual doses, typically 5–10 micrograms, to avoid psychedelic effects while seeking potential benefits.
2. Anecdotal reports and early studies suggest microdosing can enhance creativity, focus, and emotional well-being, as well as reduce symptoms of anxiety and depression.
3. The scientific understanding of microdosing is still in its early stages, with limited research on its efficacy and safety.
4. Some preliminary studies indicate that reported benefits of microdosing may partly result from placebo effects.
5. Controlled clinical trials are currently investigating the physiological and psychological effects of LSD microdosing to understand its impact better.

Historical Facts About LSD

“April 19, 1943, is celebrated annually as “Bicycle Day” because Hofmann experienced LSD’s effects while riding his bicycle home from the laboratory.”

— Katharine Chan, MSc, BSc, PMP

Take a trip through the historical timeline of LSD with these 13 facts:

The Discovery and Early Research of LSD

1. Swiss chemist Albert Hofmann first synthesized LSD in 1938 while working to isolate ergobasine, a compound with potential medical applications.
2. Hofmann labeled the substance LSD-25 because it was the 25th compound in a series of lysergic acid derivatives he was studying.
3. The scientific community largely overlooked LSD-25 until Hofmann revisited it in 1943 and accidentally absorbed a small amount through his skin, leading to an unexpected psychoactive experience.
4. On April 19, 1943, Hofmann ingested 250 micrograms of LSD, marking the first deliberate human experience with the substance.
5. April 19, 1943, is celebrated annually as “Bicycle Day” because Hofmann experienced LSD’s effects while riding his bicycle home from the laboratory.
6. Hofmann’s laboratory assistant, Susi Ramstein, became the first woman to ingest LSD on June 12, 1943, and was acknowledged as the first psychedelic guide.
7. In his book LSD — My Problem Child, Hofmann described his experience with the drug as a dreamlike state with altered perceptions, glowing colors, and kaleidoscopic visuals.

LSD’s Medical and Therapeutic Applications

8. In 1947, Sandoz introduced LSD under the brand name Delysid©, marketing it for “model psychosis” and later exploring its psychotherapeutic uses.
9. Throughout the 1950s, therapists administered LSD to thousands of patients in psycholytic and psychedelic therapy for conditions like alcoholism.
10. During the late 1940s and 1950s, researchers explored LSD’s potential in psychotherapy, finding it effective for conditions like depression, anxiety, and addiction. Researchers observed that LSD enhanced self-awareness and emotional processing in therapeutic settings.

LSD and Counterculture to Criminalization

11. In the 1960s, LSD gained popularity as a recreational drug, becoming emblematic of counterculture movements and associated with art, music, and spirituality.
12. In 1968, the United States classified LSD as a Schedule I drug, prohibiting its use and research, citing high potential for abuse and no accepted medical applications.

Modern Research and Renewed Interest

13. Since the 1990s, renewed interest in LSD has led to clinical trials investigating its safety and efficacy for mental health treatments.

Legal Facts About LSD

Get the legal scoop on LSD with these five facts:

1. LSD is classified as a controlled substance in most countries, following international agreements like the United Nations Convention on Psychotropic Substances of 1971, which requires signatory nations to prohibit it.
2. In the US, LSD is a Schedule I controlled substance under the Controlled Substances Act, indicating it has a high potential for abuse and no accepted medical use. However, some jurisdictions, such as Oregon, have experimented with decriminalization measures.
3. In Canada, the Controlled Drugs and Substances Act lists LSD under Schedule III, with unauthorized possession and trafficking carrying significant legal penalties.
4. Countries like Mexico and the Czech Republic have decriminalized the possession of small amounts of LSD, though thresholds and penalties vary. For instance, in Mexico, possession limits are explicitly defined.
5. Some countries, such as Switzerland and Australia, allow restricted use of LSD for approved medical or scientific research, with Switzerland also permitting compassionate medical use under specific circumstances.

Random Facts About LSD

Here are four facts you may not have known about LSD:

1. The US Army and CIA famously tried using LSD as a truth serum on their enemies, but it was not effective.
2. LSD use increased by over 50% between 2015 and 2018. Scientists have linked this surge to millennials and older adults facing a “bleak” outlook due to challenges like climate change and social inequality. Others suggest the rise could stem from growing positive media coverage.
3. Research indicates that LSD induces ego death more frequently than psilocybin, which may explain why some individuals find LSD experiences more intimidating. Additionally, LSD is associated with more significant cognitive, social, and functional impairments and is known to provoke anxiety, particularly at higher doses.
4. Research shows that LSD augments our emotional response to music, specifically emotions like “tenderness,” “transcendence,” “power,” and “wonder.”

A Powerful Tool for Healing and Self-Discovery

LSD’s fascinating history and potential as a therapeutic tool reveal its power to catalyze profound personal insights and healing. While its effects can be transformative, people best experience them in a safe, supportive environment under the guidance of a trained psychedelic therapist. 

If you’re curious about exploring the therapeutic potential of LSD, you can find a licensed mental health provider in our leading vetted psychedelic therapy directory.

Those interested in the latest advancements and opportunities to participate in research can visit clinicaltrials.gov to explore ongoing LSD clinical trials. With the proper support and resources, your path toward healing and self-discovery can be both meaningful and empowering.

References

Scientific Facts About LSD

Schmid, Y., Enzler, F., Gasser, P., Grouzmann, E., Preller, K. H., Vollenweider, F. X., Brenneisen, R., Müller, F., Borgwardt, S., & Liechti, M. E. (2014). Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects. Biological Psychiatry, 78(8), 544–553. https://doi.org/10.1016/j.biopsych.2014.11.015.

Therapeutic Facts About LSD

Donegan, C. J., Daldegan-Bueno, D., Sumner, R., Menkes, D., Evans, W., Hoeh, N., Sundram, F., Reynolds, L., Ponton, R., Cavadino, A., Smith, T., Roop, P., Allen, N., Abeysinghe, B., Svirskis, D., Forsyth, A., Bansal, M., & Muthukumaraswamy, S. (2023). An Open-Label Pilot Trial Assessing Tolerability and Feasibility of LSD Microdosing in Patients With Major Depressive Disorder (LSDDEP1). Pilot and Feasibility Studies, 9(1). https://doi.org/10.1186/s40814-023-01399-8.

Grof, S., Goodman, L., Richards, W., & Kurland, A. (1973). LSD-Assisted Psychotherapy in Patients with Terminal Cancer. International Pharmacopsychiatry, 8(3), 129–144. https://doi.org/10.1159/000467984.

Krebs, T. S., & Johansen, P. (2012). Lysergic Acid Diethylamide (LSD) for Alcoholism: Meta-Analysis of Randomized Controlled Trials. Journal of Psychopharmacology, 26(7), 994–1002. https://doi.org/10.1177/0269881112439253.

Gasser, P., Kirchner, K., & Passie, T. (2014). LSD-Assisted Psychotherapy for Anxiety Associated With a Life-Threatening Disease: A Qualitative Study of Acute and Sustained Subjective Effects. Journal of Psychopharmacology, 29(1), 57–68. https://doi.org/10.1177/0269881114555249.

Carhart-Harris, R. L., Kaelen, M., Bolstridge, M., Williams, T. M., Williams, L. T., Underwood, R., Feilding, A., & Nutt, D. J. (2016). The Paradoxical Psychological Effects of Lysergic Acid Diethylamide (LSD). Psychological Medicine, 46(7), 1379–1390. https://doi.org/10.1017/s0033291715002901.

Jones, S. A. V., & O’Kelly, A. (2020). Psychedelics as a Treatment for Alzheimer’s Disease Dementia. Frontiers in Synaptic Neuroscience, 12. https://doi.org/10.3389/fnsyn.2020.00034.

Random Facts About LSD

Fuentes, J. J., Fonseca, F., Elices, M., Farré, M., & Torrens, M. (2020). Therapeutic Use of LSD in Psychiatry: A Systematic Review of Randomized-Controlled Clinical Trials. Frontiers in Psychiatry, 10(943). https://doi.org/10.3389/fpsyt.2019.00943.

Holze, F., Ley, L., Müller, F., Becker, A. M., Straumann, I., Vizeli, P., Kuehne, S. S., Roder, M. A., Duthaler, U., Kolaczynska, K. E., Varghese, N., Eckert, A., & Liechti, M. E. (2022). Direct Comparison of the Acute Effects of Lysergic Acid Diethylamide and Psilocybin in a Double-Blind Placebo-Controlled Study in Healthy Subjects. Neuropsychopharmacology, 47(6), 1180–1187. https://doi.org/10.1038/s41386-022-01297-2.

Southey, M., Kathirgamalingam, A., Crawford, B., Kaul, R., McNamara, J., John-Leader, F., Heslop, J., & Pit, S. W. (2020). Patterns of Ecstasy Use Amongst Live Music Event Attendees and Their Opinions on Pill Testing: A Cross Sectional Study. Substance Abuse Treatment Prevention and Policy, 15(1). https://doi.org/10.1186/s13011-020-00295-1.

Kaelen, M., Barrett, F. S., Roseman, L., Lorenz, R., Family, N., Bolstridge, M., Curran, H. V., Feilding, A., Nutt, D. J., & Carhart-Harris, R. L. (2015). LSD Enhances the Emotional Response to Music. Psychopharmacology, 232(19), 3607–3614. https://doi.org/10.1007/s00213-015-4014-y.